Tag: Louisville vs James Madison

Louisville vs James Madison Prediction, Odds and Pick for Friday, Sept. 5, 2025

Louisville is a two-touchdown favorite over James Madison in a Friday night Week 2 matchup on ESPN2. Both teams rolled past FCS opponents in Week 1. Jeff Brohm returns 16 starters, with USC transfer Miller Moss at QB, but JMU’s ground game and disruptive defense give it a puncher’s chance. Projection: JMU covers +14.5; lean to the under.